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Hemorrhagic Transformation in Cardioembolic Cerebral Infarction
Stroke 24:465-468, Hornig,C.R.,et al, 1993
See this aricle in Pubmed

Article Abstract
Among 200 consectutive patients with transient ischemic attack or ischemic stroke,41 were identified with a computed tomographically proven supratentorital infarct due to cardiogenic embolism.Magnetic resonance imaging(T1-weighted)was performed 3 weeks after the stroke in 35 of the 41 patients.Eight patients received anticoagulants.Magnetic resonance images showed hemorrhagic transformation in 68.6%(24)of the 35 infarcts,always without clinical deterioration.In a stepwise forward logistic regression analysis only the volume of infarction edema on the initial computed tomogram was linked significantly with the risk of hemorrhagic transformation(p=0.037).Hemorrhages were a regular finding on magnetic resonance images of infarcts exceeding a volume of 10cm3(94.4%,17 of 18). Hemorrhagic transformation is a regular finding inmedium-sized and large cardioembolic infarcts.Thus,in therapeutic and preventative studies of acute stroke the severity,not the frequency,of hemorrhages into brain infarcts should e a matter of interest.
 
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